Download e-book for kindle: Handbook of LC-MS Bioanalysis: Best Practices, Experimental by Wenkui Li,Jie Zhang,Francis L. S. Tse

By Wenkui Li,Jie Zhang,Francis L. S. Tse

Consolidates the knowledge LC-MS bioanalytical scientists have to research small molecules and macromolecules

The box of bioanalysis has complicated quickly, propelled through new methods for constructing bioanalytical equipment, new liquid chromatographic (LC) concepts, and new mass spectrometric (MS) tools. additionally, there are a number of directions and rules designed to make sure the standard of bioanalytical results.

Presenting the easiest practices, experimental protocols, and the most recent figuring out of rules, this publication deals a finished evaluation of LC-MS bioanalysis of small molecules and macromolecules. It not just addresses the wishes of bioanalytical scientists engaged on regimen tasks, but additionally explores complex and rising applied sciences reminiscent of high-resolution mass spectrometry and dried blood spot microsampling.

Handbook of LC-MS Bioanalysis gains contributions from a global staff of major bioanalytical scientists. Their contributions mirror a overview of the newest findings, practices, and rules in addition to their very own firsthand analytical laboratory event. The booklet completely examines:

  • Fundamentals of LC-MS bioanalysis in drug discovery, drug improvement, and healing drug monitoring
  • The present figuring out of rules governing LC-MS bioanalysis
  • Best practices and designated technical directions for LC-MS bioanalysis approach improvement, validation, and balance evaluation of analyte(s) of interest
  • Experimental instructions and protocols for quantitative LC-MS bioanalysis of not easy molecules, together with pro-drugs, acyl glucuronides, N-oxides, reactive compounds, and photosensitive and autooxidative compounds

With its specialise in present bioanalytical perform, Handbook of LC-MS Bioanalysis allows bioanalytical scientists to increase and validate powerful LC-MS assay tools, all in compliance with present rules and standards.

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Handbook of LC-MS Bioanalysis: Best Practices, Experimental Protocols, and Regulations by Wenkui Li,Jie Zhang,Francis L. S. Tse

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