By Marc Daeron,Falk Nimmerjahn
This quantity presents a state of the art replace on Fc Receptors (FcRs). it really is divided into 5 components. half I, Old and New FcRs, bargains with the long-sought-after FcµR and the lately stumbled on FCRL kin and TRIM21. half II, FcR Signaling, offers a computational version of FcεRI signaling, novel calcium channels, and the lipid phosphatase SHIP1. half III, FcR Biology, addresses significant physiological services of FcRs, their glycosylation, how they result in and keep an eye on either adaptive immune responses and irritation, specially in vivo, FcR humanized mice, and the multifaceted houses of FcRn. half IV, FcRs and Disease, discusses FcR polymorphism, FcRs in rheumatoid arthritis and even if their FcRs make macaques solid versions for learning HIV an infection. partially V, FcRs and healing Antibodies, the jobs of assorted FcRs, together with FcγRIIB and FcαRI, within the immunotherapy of melanoma and autoimmune ailments utilizing monoclonal antibodies and IVIg are highlighted. All 18 chapters have been written by way of revered specialists of their fields, supplying a useful reference resource for scientists and clinicians attracted to FcRs and the way to higher grasp antibodies for healing purposes.
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Fc Receptors (Current Topics in Microbiology and Immunology) by Marc Daeron,Falk Nimmerjahn